Evid Based Complement Alternat Med. 2018 2018():3037120-3037120 doi: 10.1155/2018/3037120.
Antidiarrheal Activity of 80% Methanolic Leaf Extract of .
Belay Mekonnen; Assefa Belay Asrie; Zewdu Birhanu Wubneh
Hospital Pharmacy, University of Gondar, Gondar, Ethiopia.; Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.; Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Diarrhea is one of the leading causes of preventable death in developing countries and mainly affects children and infants. It has been reported that the leaf of is used as an antidiarrheal agent in Libo Kemekem district, northwest Ethiopia. Method: The 80% methanolic leaf extract of was evaluated for its activity against castor oil-induced diarrhea, enteropooling, and gastrointestinal motility in mice. Results: Significant reduction ( < 0.001) in the total defecation and diarrheal drops was produced by all the test doses of the extract. Percentage inhibition of wet feces was 42.58, 65.07, and 74.96% at 100, 200, and 400 mg/kg doses of the extract, respectively. The extract also significantly inhibited castor oil-induced enteropooling at all test doses. The percent reduction in mean weight of intestinal contents was 66.96, 67.83, and 76.52% at 100, 200, and 400 mg/kg doses of the extract, respectively. The extract significantly reduced gastrointestinal movement of charcoal meal as well at 200 ( < 0.01) and 400 mg/kg ( < 0.001) doses. Conclusion: In conclusion, the methanolic leaf extract of has an antidiarrheal activity and this supports the use of this plant in the treatment of diarrhea in the traditional settings.
Article Type: Journal Article